Legis
Healthcare
Executive order · Tuesday 30 September 2025

Unlocking Cures For Pediatric Cancer With Artificial Intelligence

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  • The Administration aims to drive innovation in preventing and treating childhood diseases, particularly pediatric cancer, which is the leading cause of disease-related death for children aged 1-19 in the U.S.
  • The Make America Healthy Again (MAHA) Commission, established by Executive Order 14212, prioritizes reversing the increasing trend of pediatric cancer incidence, with artificial intelligence (AI) seen as a vital tool.
  • The Childhood Cancer Data Initiative (CCDI) was created in 2019, providing $50 million annually for 10 years to enhance the collection and analysis of childhood cancer data, establishing a foundational data infrastructure for new discoveries.
  • AI will be leveraged to improve diagnostics, treatment options, and research methodologies related to pediatric cancer, helping to develop superior medical strategies and ultimately save lives.
  • The MAHA Commission will collaborate with various health and technology leaders to implement AI advancements for better diagnosis and treatment strategies, focusing on:
    • Enhancing data infrastructure and participant selection for clinical trials.
    • Utilizing AI for predictive modeling of patient responses and treatment outcomes.
    • Optimizing clinical trial designs to improve patient access and outcomes.
  • The Commission will also seek to increase federal funding for pediatric cancer initiatives and encourage private sector investment in AI-based technological solutions.
  • The Secretary of Health and Human Services will work on integrating AI into existing interoperability efforts to enhance the utility of electronic health records and ensure patient data privacy.
  • Additionally, there will be a focus on establishing interoperable standards for patient data that consider both structured and unstructured data for safe, privacy-compliant exchanges.
  • The order clarifies the non-impairment of existing agency authorities, requires implementation according to applicable laws and appropriations, and states it does not create enforceable rights for individuals against the U.S. or its entities.